.content {
	max-width: 1300px;
	width: 80%;
	margin: 0 auto;
}

img {
	max-width: 100%;
}

.modal {
	position: fixed;
	top: 50%;
	left: 50%;
	width: 50%;
	max-width: 630px;
	min-width: 250px;
	height: auto;
	z-index: 2000;
	visibility: hidden;
	background: #373F58;
	-webkit-backface-visibility: hidden;
	-moz-backface-visibility: hidden;
	backface-visibility: hidden;
	-webkit-transform: translateX(-50%) translateY(-50%);
	-moz-transform: translateX(-50%) translateY(-50%);
	-ms-transform: translateX(-50%) translateY(-50%);
	transform: translateX(-50%) translateY(-50%);
}

.show {
	visibility: visible;
}

.overlay {
	position: fixed;
	width: 100%;
	height: 100%;
	visibility: hidden;
	top: 0;
	left: 0;
	z-index: 1000;
	opacity: 0;
	-webkit-transition: all 0.3s;
	-moz-transition: all 0.3s;
	transition: all 0.3s;
}

.show ~ .overlay {
	opacity: 1;
	visibility: visible;
}

.popup-content {
	color: #fff;
	position: relative;
	border-radius: 3px;
	margin: 0 auto;
	padding: 6%;
}

.popup-content h3 {
	margin: 0;
	text-align: center;
	font-size: 2em;
	font-weight: 300;
	position: relative;
}

.popup-content .para {
	color: #73556b;
	margin-bottom: 30px;
	text-align: justify;
}

.popup-content > div {
	padding: 0px;
	margin: 0;
	font-weight: 300;
	font-size: 1.15em;
}

.popup-content > div p {
	margin: 0;
	padding: 10px 0;
	color:#fff;
}




.popup-content button {
	display: block;
	margin: 0 auto;
	font-size: 0.8em;
}

.close {
	background: url('../images/popup-close.png') no-repeat;
	height: 49px;
	width: 49px;
	position: absolute;
	right: -35px;
	top: -35px;
	z-index: 9999;
	cursor: pointer;
	opacity: 1;
	-webkit-transition: all ease-in-out 0.3s;
	-o-transition: all ease-in-out 0.3s;
	transition: all ease-in-out 0.3s;
}

.close:hover {
	opacity: 0.2;
}



.show.blur-effect ~ .overlay {
	background:rgba(0, 0, 0, 0.4);
}

.show.blur-effect ~ .container, .show.blur-effect ~ .bgall{
	-webkit-filter: blur(30px);
	-moz-filter: blur(30px);
	filter: blur(30px);
}

.blur-effect .popup-content {
	-webkit-transform: translateY(-5%);
	-moz-transform: translateY(-5%);
	-ms-transform: translateY(-5%);
	transform: translateY(-5%);
	opacity: 0;
}

.show.blur-effect ~ .container,
.blur-effect .popup-content, .show.blur-effect ~ .bgall {
	-webkit-transition: all 0.3s;
	-moz-transition: all 0.3s;
	transition: all 0.3s;
}

.show.blur-effect .popup-content {
	-webkit-transform: translateY(0);
	-moz-transform: translateY(0);
	-ms-transform: translateY(0);
	transform: translateY(0);
	opacity: 1;
}
.popup_color{
	color:#FF674A;
}
.label_pupup{
	width: 38%;
    display: inline-block;
    vertical-align: top;
}
.value_popup{
	 width:60%;
    display: inline-block;
    margin-left:0%;
	color:#FF674A;
	font-size:24px;
}



.popup-content small.vt-top{
	vertical-align: top;
    font-family: initial;
    font-size: 14px;
}

.popup-content > div > div{
	margin-bottom:10px;
}
.popup-button{
	color:#0000FF !important;
	cursor:pointer;
}

button.popup-button{
    color: red !Important;
}


#popup3 .vt-bottom,
#popup5 .vt-bottom,
#popup6 .vt-bottom,
#popup7 .vt-bottom{
	font-size: 10px;
    padding-top: 5px;
    display: inline-block;
    vertical-align: top;
    margin-left: 3px;
}




#popup .value_popup,
#popup1 .value_popup,
#popup3 .value_popup,
#popup4 .value_popup,
#popup5 .value_popup,
#popup6 .value_popup,
#popup7 .value_popup{
	width:85%;
	font-size:18px;
	color:#fff;
}
#popup .label_pupup,
#popup1 .label_pupup,
#popup3 .label_pupup,
#popup4 .label_pupup,
#popup5 .label_pupup,
#popup6 .label_pupup,
#popup7 .label_pupup{
	width:13%;
	color:#FF674A;
	font-size:20px;
}

.value_popup1{
	width: 84%;
	color: #fff;
	font-size: 18px;
	display: inline-block;
    margin-left: 0%;
}

.label_pupup1{
	width:15%;
	color:#FF674A;
	font-size:20px;
	display: inline-block;
    vertical-align: top;
}

.max-amount1 .box_border1 .no-label {
    padding: 25px 10px;
}

.box_border1.no-label > span {
    margin-top: 0px !important;
}


.max-amount1 {
    text-align: center;
}


.max-amount1 > span.box_border1{
	text-align: center;
	overflow: hidden;
    display: inline-block;
    width: 45%;
	border: 3px solid #FF674A;
	padding:10px;
	cursor:pointer;
	-webkit-transition: all 0.5s ease;
    -moz-transition: all 0.5s ease;
    -ms-transition: all 0.5s ease;
    -o-transition: all 0.5s ease;
    transition: all 0.5s ease;
}

.max-amount1 > span.box_border1:hover{
	background-color:transparent;
        cursor: auto;
}


.box_border1 > span{
	display:inline-block;
	vertical-align:top;
	color: #fff;
    font-size: 22px;
}
.box_border1 span small,
.amount-lable small{
	font-family: initial;
}
.box_border1 span.first-vlu small{
	font-family: initial;
	margin-left:5px;
	margin-right:10px;
	display:inline-block;
}
.box_border1 p{
	border-bottom: 1px solid #fff;
    font-size: 22px;
	min-width:100px;
	margin-bottom: 5px !important;
    padding-bottom: 5px !important;
        padding: 0 0 !important;
}
.box_border1 > span.first-vlu{
	margin-top: 10px;
    margin-right: 10px;
}


.popup-bottom-value{
	font-size: 10px;
    padding-top: 5px;
    display: inline-block;
    
    margin-left: 3px;

}


.popup-value-left{
	width: 38%;
	display: inline-block;
	color: #fff;
	font-size: 16px;
	vertical-align: top;
}

.popup-formula-right{
	width: 60%;
	display: inline-block;
	font-size: 24px;
	margin-left: 0%;
	color: #fff;
}

span.integral {
    width: 20%;
    padding-top: 5px;
}

.popup-formula-left1{
	width: 48%;
	display: inline-block;
	font-size: 24px;
	margin-left: 0%;
	color: #fff;
}
.popup-formula-right1{
	width: 48%;
	display: inline-block;
	font-size: 24px;
	margin-left: 0%;
	color: #fff;
}

.box_border3{
	    padding-bottom: 0px !important; 

}


small.top-value1 {
    font-family: initial;
    margin-left: -5px;
    vertical-align: middle;
    margin-bottom: 50px !important;
    display: inline-block;
}

small.bottom-value1 {
    font-family: initial;
    margin-left: 20px;
    vertical-align: middle;
    margin-top: -34px;
    display: inline-block;
}


.max-amount2 .box_border2 .no-label {
    padding: 25px 10px;
}

.box_border2.no-label > span {
    margin-top: 0px !important;
}


.max-amount2 {
    text-align: center;
}


.max-amount2 > span.box_border2{
	text-align: center;
	overflow: hidden;
    display: inline-block;
    width: 100%;
	border: 3px solid #FF674A;
	padding:5px;
	cursor:pointer;
	-webkit-transition: all 0.5s ease;
    -moz-transition: all 0.5s ease;
    -ms-transition: all 0.5s ease;
    -o-transition: all 0.5s ease;
    transition: all 0.5s ease;
}

.max-amount2 > span.box_border2:hover{
	background-color:transparent;
}


.box_border2 > span{
	display:inline-block;
	vertical-align:top;
	color: #fff;
    font-size: 22px;
}
.box_border2 span small,
.amount-lable small{
	font-family: initial;
}
.box_border2 span.first-vlu small{
	font-family: initial;
	margin-left:5px;
	margin-right:10px;
	display:inline-block;
}
.box_border2 p{
	padding: 0px 0px !important;
	border-bottom: 1px solid #fff;
    font-size: 22px;
	min-width:100px;
	margin-bottom: 5px !important;
    padding-bottom: 5px !important;
}
.box_border2 > span.first-vlu{
	margin-top: 15px;
    margin-right: 10px;
}

#time-to-steady-state .box_border2 > span, #time-to-steady-state .box_border2 p {
    font-size: 15px;
}

#time-to-steady-state .box_border2 p{
    padding-bottom: 0px !important;
    min-width: 55px;
}

#time-to-steady-state .box_border2 > span.first-vlu{
    margin-right: 0px;
    margin-top: 18px;
}



#linear-simulation #popup10 input#x-value, #linear-simulation #popup11 input#y-value{
    margin: 0px auto;
    display: block;
    margin-bottom: 10px; 
    padding: 12px 20px;
    border: 1px solid #ccc;
    border-radius: 4px;
    box-sizing: border-box;
    
}

#linear-simulation #popup10 .popup-content .button, #linear-simulation #popup11 .popup-content .button{
    width: inherit;
    margin-left: auto;
}


#linear-simulation #popup10 .popup-content > div, #linear-simulation #popup11 .popup-content > div{
    margin-top: 15px;
}



#semilog-simulation #popup10 input#x-value, #semilog-simulation #popup11 input#y-value{
    margin: 0px auto;
    display: block;
    margin-bottom: 10px; 
    padding: 12px 20px;
    border: 1px solid #ccc;
    border-radius: 4px;
    box-sizing: border-box;
    
}

#semilog-simulation #popup10 .popup-content .button, #semilog-simulation #popup11 .popup-content .button{
    width: inherit;
    margin-left: auto;
}


#semilog-simulation #popup10 .popup-content > div, #semilog-simulation #popup11 .popup-content > div{
    margin-top: 15px;
}



/* Media queries */

@media(max-width: 1230px) {

	.popup-content h3:before {
		display: none;
	}	

}


@media (max-width: 810px){
    .modal{
        min-width: 680px;
    }
}

@media(max-width: 770px){
    .value_popup{
        font-size: 16px;
    }
    
    .modal{
            min-width: 600px;
    }
    .label_pupup1{
        font-size: 18px;
    }
}

@media(max-width: 680px) {
        .modal .label_pupup {
                font-size: 14px;
        }
	.modal p {
                font-size: 14px;
	}
	.modal .value_popup {
                font-size: 14px;
	}
	.modal {
                min-width: 80%;
                max-width:90%;
                max-height: 90%;
                overflow: hidden;
                overflow-y: auto;
	}

	.modal h1 {
		font-size: 32px;
	}

	.popup-content h3 {
		font-size: 1.5em;
	}

	.close {
		right: 1px;
		top: 1px;
	}
	.max-amount1 > span.box_border1{
		width: 85%;
		padding: 1px;
		border: 2px solid #FF674A;
	}

	.box_border1 > span{
		font-size: 14px;
	}

	.modal .popup-content > div p{
		padding: 1px;
	}

	.box_border1 p{
		font-size: 14px;
	}

	.max-amount2 > span.box_border2{
		border: 1px solid #FF674A;
                padding: 0px;
	}

	.modal .popup-value-left{
		font-size: 14px;
		width: 30%;
	}
	.modal .popup-formula-right{
		width: 68%;
	}		

	.modal .box_border2 > span
	{
		font-size: 14px;
	}

	.modal .box_border2 p{
		font-size: 14px;
	}

	#popup .value_popup, #popup1 .value_popup, #popup3 .value_popup, #popup4 .value_popup, #popup5 .value_popup, #popup7 .value_popup{
		font-size: 14px;
	}


	#popup .label_pupup, #popup1 .label_pupup, #popup3 .label_pupup, #popup4 .label_pupup,	#popup5 .label_pupup,	#popup7 .label_pupup{
		font-size: 14px;
	}

	.popup-formula-right1{
		width: 100%;
	}

	.popup-formula-left1{
		width: 100%;
	}

	span.integral{
		width: 18%;
		padding-top:0px;
	}

	#loading-dose2 .modal .popup-content > div p{
		padding: 1px;
			}


	.label_pupup1 {
                font-size: 14px;
	}

	.value_popup1 {
                font-size: 14px;
	}


	.box_border > span{
		font-size: 14px;
	}

	.box_border p{
		font-size: 14px;
	}


	.modal span.label{
		font-size: 14px;
	}


	.modal .space4x{
		margin-top: 22px;
	}


	.modal .rate_administration, .modal .rate_elimination{
		width: 15%;
	}


	.modal .amount_rate2 .arrows{
		width: 100%;
	}
        
        #time-to-steady-state .modal .popup-value-left{
            margin-bottom: 10px;
        }
        
        #loading-dose2 #popup3 .max-amount2 > span.box_border2, #loading-dose2 #popup3 .max-amount1 > span.box_border1{
            width: 70%;
            padding: 5px 0px;
        }

	
}

@media(max-width: 480px) {
	.modal .label_pupup {
                font-size: 14px;
	}
	.modal p {
                font-size: 12px;
	}
	.modal .value_popup {
                font-size: 12px;
	}
	.modal {
                max-width: 95%;
                min-width: 90%;
                max-height: 90%;
                overflow: hidden;
                overflow-y: auto;
	}

	.modal h1 {
		font-size: 32px;
	}

	.popup-content h3 {
		font-size: 1.3em;
	}

	.close {
		right: 1px;
		top: 1px;
	}
	.max-amount1 > span.box_border1{
		width: 85%;
		padding: 1px;
		border: 1px solid #FF674A;
	}

	.box_border1 > span{
		font-size: 12px;
	}

	.modal .popup-content > div p{
		padding: 1px;
	}

	.box_border1 p{
		font-size: 12px;
	}

	.max-amount2 > span.box_border2{
		border: 1px solid #FF674A;
            padding: 0px;
	}

	.modal .popup-value-left{
		font-size: 12px;
		width: 30%;
	}
	.modal .popup-formula-right{
		width: 68%;
	}		

	.modal .box_border2 > span
	{
		font-size: 12px;
	}

	.modal .box_border2 p{
		font-size: 12px;
	}

	#popup .value_popup, #popup1 .value_popup, #popup3 .value_popup, #popup4 .value_popup, #popup5 .value_popup, #popup7 .value_popup{
		font-size: 12px;
	}


	#popup .label_pupup, #popup1 .label_pupup, #popup3 .label_pupup, #popup4 .label_pupup,	#popup5 .label_pupup,	#popup7 .label_pupup{
		font-size: 14px;
	}

	.popup-formula-right1{
		width: 100%;
	}

	.popup-formula-left1{
		width: 100%;
	}

	span.integral{
		width: 27%;
		padding-top:0px;
	}

	#loading-dose2 .modal .popup-content > div p{
		padding: 1px;
			}


	.label_pupup1 {
                font-size: 14px;
	}

	.value_popup1 {
                font-size: 12px;
	}


	.box_border > span{
		font-size: 12px;
	}

	.box_border p{
		font-size: 12px;
	}


	.modal span.label{
		font-size: 12px;
	}

	.modal .space4x{
		margin-top: 22px;
	}


	.modal .rate_administration, .modal .rate_elimination{
		width: 15%;
	}

	.modal .amount_rate2 .arrows{
		width: 100%;
	}
        
        
        #plasma-concentration2  #popup4 .label_pupup{
            width: 18%;
        }
        #plasma-concentration2  #popup4 .value_popup{
            width: 80%;
        }
        
        #loading-dose2 #popup4 .label_pupup1{
            width: 20%;
        }
        #loading-dose2 #popup4 .value_popup1{
            width: 78%;
        }
        
        #loading-dose2 #popup4 .label_pupup1 > small.vt-bottom{
            font-size: 12px;
        }
        
        #time-to-steady-state .box_border2 > span, #time-to-steady-state .box_border2 p {
        font-size: 12px;
        }

        #time-to-steady-state .box_border2 p{
            padding-bottom: 0px !important;
            min-width: 40px;
        }

        #time-to-steady-state .box_border2 > span.first-vlu{
            margin-right: 0px;
            margin-top: 18px;
        }
        
        #time-to-steady-state .box_border2 > span.first-vlu .vt-bottom, #time-to-steady-state .modal .popup-value-left .vt-bottom{
            font-size: 11px;
        }
        
        #time-to-steady-state .modal .popup-value-left{
            margin-bottom: 10px;
        }
        
        #dosage-regimen-design5 #popup3 .label_pupup1, #dosage-regimen-design6 #popup1 .label_pupup1{
            width: 22%;
            font-size: 13px;
        }
        #dosage-regimen-design5 #popup3 .value_popup1, #dosage-regimen-design6 #popup1 .value_popup1{
            width: 76%;
        }
        
        #dosage-regimen-design5 #popup3 .label_pupup1 >small.bottom-value, #dosage-regimen-design6 #popup1 .label_pupup1 >small.bottom-value{
                margin-left: 0px;
                vertical-align: top;
                margin-top: 6px;
                font-size: 12px;
        }
        
        #dosage-regimen-design6 #popup2 .label_pupup1{
            width: 18%;
        }
        #dosage-regimen-design6 #popup2 .value_popup1{
            width: 80%;
        }
        #dosage-regimen-design6 #popup2 .label_pupup1 >small.vt-bottom{
                
                font-size: 12px;
        }
        
        
        
}



@media(max-width: 360px) {
    
        #loading-dose2 #popup4 .label_pupup1{
            width: 23%;
        }
        #loading-dose2 #popup4 .value_popup1{
            width: 75%;
        }
        
        #loading-dose2 #popup4 .label_pupup1 > small.vt-bottom{
            font-size: 10px;
        }
        
        #dosage-regimen-design5 #popup3 .label_pupup1, #dosage-regimen-design6 #popup1 .label_pupup1{
            width: 22%;
            font-size: 12px;
        }
        
        #dosage-regimen-design5 #popup3 .value_popup1, #dosage-regimen-design6 #popup1 .value_popup1{
            width: 76%;
        }
        
        #dosage-regimen-design6 #popup2 .label_pupup1{
            width: 22%; 
        }
        #dosage-regimen-design6 #popup2 .value_popup1{
            width: 76%;
        }
        
        #dosage-regimen-design6 #popup2 .label_pupup1 > small.vt-bottom{
            font-size: 12px;
        }
        
        #dosage-regimen-design5 #popup3 .label_pupup1 >small.bottom-value, #dosage-regimen-design6 #popup1 .label_pupup1 >small.bottom-value{
                margin-left: 0px;
                vertical-align: top;
                margin-top: 6px;
                font-size: 11px;
        }
        
        #time-to-steady-state .box_border2 > span, #time-to-steady-state .box_border2 p {
        font-size: 12px;
        }

        #time-to-steady-state .box_border2 p{
            padding-bottom: 0px !important;
            min-width: 30px;
        }

        #time-to-steady-state .box_border2 > span.first-vlu{
            margin-right: 0px;
            margin-top: 18px;
        }
        
        #time-to-steady-state .box_border2 > span.first-vlu .vt-bottom, #time-to-steady-state .modal .popup-value-left .vt-bottom{
            font-size: 10px;
        }
        
        #time-to-steady-state .modal .popup-value-left{
            margin-bottom: 10px;
        }
        
        .modal .label_pupup{
            font-size: 12px;
        }
        .modal .popup-value-left{
            font-size: 10px;
        }

}