Questions

Propranolol is a beta-adrenergic blocker used in the treatment of hypertension. The AUC observed after administration of a single propranolol dose of 100 mg in a patient with normal liver function was 0.5 mg-hr/L. What will be the difference if the same dose was administered to a patient with severe liver failure if you know that the liver is the main route for propranolol elimination ?

1 - Propranolol clearance will be higher and the AUC will be larger 2 - Propranolol clearance will be lower and the AUC will be larger 3 - Propranolol clearance will be lower and the AUC will be smaller 4 - Propranolol clearance will be higher and the AUC will be smaller